Potentiation of Lithium with Carbamazepine in Acute Mania
نویسندگان
چکیده
In a 6 month prospective randomized open trial addition of 400 mgs. of carbamazepine per day to lithium carbonate was assessed. Although statistically non-significant, the trends suggest that use of carbamazepine hastens recovery and leads to less frequent use of emergency sedation without any increase in side effects.
منابع مشابه
مقایسه اثر لیتیوم،کاربامازپین و والپروئات در درمان مرحله حاد مانیای کلاسیک
The purpose of this study was to compare the effectiveness of three common mood stabilizing drugs, Lithium, Carbamazepine and Valproate in the treatment of acute mania Of the 114 patients who participated in this study, 60 were treated with Lithium, 30 with Carbamazepine and 24 with Valproate. This study was a prospective and double blind study. The patients were assessed by GAF Scale and a man...
متن کاملA Comparative Study of Side-effects of Lithium, Carbamazepine and Haloperidol in Acute Mania
In an open trial on manic patients, side-effects of carbamazepine, lithium and haloperidol were evaluated weekly over a 4-week period. The total side-effects with the three drugs were not significantly different, but the rate of amelioration of the same was best for lithium and least for haloperidol. It was indicative that lithium was better tolerated drug than the other two.
متن کاملSummary of the Recent Literature on Bipolar Disorder
Acute Mania Quetiapine XR (FDA approved for the treatment of acute mania) monotherapy has been shown to be more effective than placebo in treating acute mania with improvement starting at day 4. Aripiprazole adjunctive therapy was more effective than placebo adjunctive therapy in treating manic symptoms in BD manic patients with inadequate response to lithium or divalproex in a 6 week trial. Ol...
متن کاملPharmacological management of bipolar disorder:a review
Results and conclusions For treatment of acute mania lithium, valproate and carbamazepine are more effective than placebo but they have no superiority over antipsychotics. There is evidence from RCTs that second generation antipsychotics (SGA) are more effective than placebo. Haloperidol may be more effective than SGA in treatment of acute mania. Combination of antipsychotic and mood stabiliser...
متن کاملمقایسه اثربخشی اولانزاپین و لیتیوم کربنات در درمان حمله حاد مانیا، یک مطالعه دوسوکور
Background & Aims : Bipolar Mood Disorder in acute manic episode is one of the psychiatric emergencies and usually needs to be admitted and intensive management. Treatment of these episodes ordinarily need mood stabilizer together with antipsychotic drugs. Although lithium carbonate is effective in acute mania alone, it needs more time to control episode. Only a few studies have been done a...
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